September 9, 2026
HS5 vs IM8 vs Tmrw Review: Ingredients, Price and Formula Compared
Something has changed in how women over 40 shop for a daily supplement, and it starts with a better question. Not “what can I take to feel healthier?” but “what will actually change, and how will I know?”
That question sorts this category fast.
Three products dominate the feeds right now: IM8, co-founded by David Beckham, Tmrw, the newer longevity entrant, and HS5. They are advertised to the same woman in similar language. They are not built for the same job, and the differences matter more than the packaging suggests.
How We Compared These Products
We used each brand’s own published information: supplement panels, ingredient lists, serving sizes, subscription and one-time pricing, and current advertising. Where a brand does not disclose an amount, we say so rather than estimating.
We did not test the products in a lab, and we did not run a clinical trial. Where we reference research, it is published research on individual ingredients, listed at the end of this article, not studies of these three specific products.
We sell HS5. Read this the way you would read any comparison written by a company that makes one of the products in it, and check the labels yourself.
What Should a Daily Powder Do for a Woman Over 40?
Before comparing brands, it helps to decide what you actually want the product to do. What a 45-year-old woman needs is not what a 25-year-old athlete needs. Most all-in-one powders are built for a general adult, not for her.
IM8 and Tmrw cover the last one well. HS5 is built for the first six.
At a glance
Formulation Philosophy
Here is how each brand approaches the problem at the highest level.
Core philosophy
Visible results women can verify
Broad micronutrient coverage
Cellular longevity science
Strengths
Gram-dose actives; peptides, fiber and hyaluronic acid; lowest cost per serving; 1,283 verified reviews
Wide vitamin and mineral base; CoQ10 and MSM at clinical levels; NSF Certified for Sport
500 mg NMN; transparent per-ingredient dosing; 10 probiotic strains
Limitations
Not a multivitamin; does not replace a micronutrient formula
No peptides or hyaluronic acid; full stack requires two products
No peptides or hyaluronic acid; benefits are not observable short-term
Cost per serving
$1.96 (subscription)
$2.97 (subscription)
$2.96 (subscription)
Already the gap begins to show. These formulas are engineered toward completely different definitions of what a daily supplement is for.
The Serving Size Reality Check
Every all-in-one powder advertises its ingredient count. IM8 lists more than 90. Tmrw lists 88.
Neither puts the serving weight on the front of the package, and that number determines everything.
IM8 ships in single-serve sachets weighing 13.6 to 14.4 grams. That is the entire serving. Ninety-plus ingredients, plus flavoring and the berry base, inside roughly fourteen grams.
Vitamins, minerals, extracts
milligrams, micrograms
1 mg to 900 mg
Yes, ninety of them
Protein peptides
grams
10 to 20 g
No
Viscous soluble fiber
grams
3 to 5 g
Only partially
Hyaluronic acid
milligrams
100 to 200 mg
Yes, but not included
HS5 delivers 18.14 grams of protein peptides in a single scoop. That is more than the entire weight of an IM8 sachet.
This is not a criticism of their formulating. It is a physical constraint. A fourteen-gram sachet can hold a great many things measured in milligrams and almost nothing measured in grams, which is why both all-in-one products deliver micronutrients and neither delivers protein peptides or hyaluronic acid.
Product 01
IM8: Built for Micronutrient Coverage, Not Visible Change
IM8 offers genuine micronutrient density and a well-formed vitamin and mineral base.
Where it succeeds
- CoQ10 at 100 mg and MSM at 1,000 mg, both at levels the research supports
- Bioavailable nutrient forms, including methylated B12 and P-5-P B6
- Pre-, pro- and postbiotic blend
- NSF Certified for Sport
Where it falls short for this buyer
- No protein peptides and no hyaluronic acid, so skin structure, hair and nails are unaddressed
- Full coverage requires Essentials plus Longevity: two products and two subscriptions
- Its menopause advertising names outcomes while noting it is nutritional rather than hormonal support
- Many advertised outcomes are ones you take largely on trust rather than observe
Product 02
Tmrw: Built for Longevity Compounds, Not Daily Experience
Tmrw is the more transparent of the two on dosing, and it does not hide behind proprietary blends.
Where it succeeds
- 500 mg NMN, CaAKG and TMG, dosed and disclosed
- 10 probiotic strains rather than a spore-only approach
- Thaumatin instead of stevia
- NSF-certified manufacturing
Where it falls short for this buyer
- Same fourteen-gram constraint: no protein peptides and no hyaluronic acid
- Its own materials describe meaningful change over months and years and recommend at least three months
- Nothing in the formula targets skin, hair, nails or appetite
- At $2.96 a serving it is priced identically to IM8 while covering a narrower set of daily needs
Product 03
HS5: Built Backwards From What Women Actually Notice
HS5 starts from a different question: what sent her looking in the first place?
It is almost never a lab panel. It is a morning in front of the mirror. The skin along the jaw sits differently. The ponytail feels thinner. Rings turn. The jeans button, but not the way they did in March.
What HS5 includes
- 18.14 g protein peptides and 20 amino acids from grass-fed bovine, wild-caught Alaskan fish, cage-free chicken and eggshell membrane
- 160 mg hyaluronic acid for skin hydration and joint lubrication support
- Glucomannan, a thick konjac root soluble fiber studied for digestive health and appetite support
- 180 mg vitamin C at 200% DV, required for the body’s own connective tissue synthesis
- L-Carnitine L-Tartrate for energy metabolism
- Unflavored: one scoop mixes into coffee or a smoothie
- Made in the USA in an FDA-registered GMP facility and third-party tested
Who formulated it
HS5 was developed by Michelle Baldini, founder and owner of Healthful Seasons, working with Natalie Bilinovich, MSN, APRN, CNP, Clinical Partner, Healthful Seasons, whose practice is in dermatology, and a veteran supplement formulator at an FDA-registered, GMP-certified facility. Every batch is third-party tested for purity and potency.
The amounts were chosen by people who work with skin and supplement manufacturing—not picked to make a longer ingredient list.
Rather than trying to be a multivitamin with extras, HS5 covers the gram-dose actives a micronutrient sachet has no room for.
Skin, Hair and Nail Support
This is the category where the gap is widest.
- Protein peptides
- 18.14 g
- Glycine, proline, hydroxyproline profile
- Yes, 20 amino acids
- Hyaluronic acid
- 160 mg
- Vitamin C
- 180 mg
- Protein peptides
- None
- Glycine, proline, hydroxyproline profile
- No
- Hyaluronic acid
- None
- Vitamin C
- 900 mg
- Protein peptides
- None
- Glycine, proline, hydroxyproline profile
- No
- Hyaluronic acid
- None
- Vitamin C
- 400 mg
Skin structure, hair and nails are built from amino acids. No quantity of micronutrients substitutes for the raw material, and neither all-in-one formula contains any.
Gut Health and Digestive Support
All three say they support digestion. They go about it in very different ways.
- Probiotic strains
- None
- Dietary fiber
- Glucomannan, a thick soluble fiber
- Amino acids
- 20 amino acids, high in glycine
- Probiotic strains
- Spore-based Bacillus, 10B CFU
- Dietary fiber
- 3 g total dietary fiber per serving
- Amino acids
- None
- Probiotic strains
- 9 lactobacillus and bifidobacterium plus 1 spore strain, 10B CFU
- Dietary fiber
- Prebiotics and digestive enzymes
- Amino acids
- None
Think of it as three jobs.
Probiotics add good bacteria. Fiber feeds that bacteria and keeps things moving. Amino acids are what your gut lining is built from.
IM8 and Tmrw both focus on the first job. Tmrw uses ten strains, which is the broader mix of the two. HS5 does the other two.
Glucomannan is not ordinary fiber. It comes from konjac root, and it soaks up many times its weight in water to form a gel in your stomach. That gel adds bulk and moisture, which supports regularity. And it takes up space, which helps you feel full. Both effects have been studied in reviews of randomized trials.
It is also why HS5 is thicker than most drink mixes. That is the fiber doing its job, not a mixing problem.
The amino acids matter here too. Your gut lining is made of protein, and glycine is one of the main amino acids in it. HS5 gives you 18.14 grams of protein peptides, high in glycine. Neither of the other two gives you any real amount, because there is no room for it in a fourteen-gram packet.
Here is the practical part. Most American adults do not get enough fiber. Almost no one is short on probiotic pills. A daily drink that adds a thick soluble fiber fills the gap most women actually have. It is also the one thing on this list you notice at your next meal instead of next season.
Ingredient Considerations
Vitamin C amounts differ a lot
IM8 has 900 mg. Tmrw has 400 mg. HS5 has 180 mg, which is twice the daily value. Your body needs vitamin C to build connective tissue, and 180 mg covers that job without going high for the sake of a bigger number on the label.
One product or two
IM8’s full routine means buying two products and taking both. HS5 is one scoop.
Price and value
One Scoop. Lower Cost. More You Can Measure.
One-time
$48.89 (20 servings)
$112 (30 servings)
$119 (30 servings)
Subscription
$39.11 (20% off)
$89/mo
$89/mo
Per serving (sub)
$1.96
$2.97
$2.96
30-day equivalent
~$58.67
$89
$89
Full stack required?
No
Yes, $196/mo
No
Guarantee
60 days, even empty
30 to 90 days
30 days
HS5 is the clear value winner. At $1.96 a serving it costs roughly a third less than either alternative, and it is the only one of the three whose complete offering is a single product.
IM8’s full coverage runs $196 a month across two subscriptions. That is more than three times HS5’s 30-day equivalent, for a formula that does not address skin, hair, nails or satiety at all.
The verdict
HS5 is our pick for women over 40.
It is the only formula here that delivers gram-dose actives. 18.14 grams of protein peptides with a 20 amino acid profile, 160 mg of hyaluronic acid, and a viscous soluble fiber. Those are the inputs behind skin hydration and elasticity, hair, nails, joint comfort, digestive regularity and satiety. Neither IM8 nor Tmrw contains any of them.
It is the only one that works both sides of gut health: fiber and amino acids, rather than probiotic strains alone.
It is the cheapest, at $1.96 a serving against $2.97 and $2.96. IM8’s complete offering runs $196 a month across two subscriptions, more than three times HS5’s thirty-day equivalent.
And it is the only one you can actually evaluate. The research window on peptide supplementation runs four to twelve weeks. You have a mirror, you have hands, you get dressed every morning, and you will know how you feel at eleven in the morning. By spring you will have your own answer, and you will not need anyone to interpret it for you.
Where IM8 still makes sense
Need broad micronutrient coverage and want to retire a shelf of bottles? IM8 does that job well, and its CoQ10 and MSM dosing is genuinely strong.
Where Tmrw still makes sense
Want NAD+ compounds specifically, and would otherwise buy NMN and CaAKG separately? Tmrw is the more transparent formulation and the better value in that narrow case.
Already taking one of them? Keep it, and add HS5. It is unflavored, mixes into the same morning coffee, and requires no second ritual. Starting from scratch? Start with the one you can check.
Try HS5
Start with the one you can check.
- 60-day money-back guarantee, honored even on an empty container
- Save 20% on subscription, update or cancel anytime
- Free shipping over $80
- 20 servings, unflavored
60-day money-back guarantee
References +
- 1.Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2014;27(1):47-55.
- 2.Proksch E, Schunck M, Zague V, Segger D, Degwert J, Oesser S. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin Pharmacol Physiol. 2014;27(3):113-119.
- 3.Kim DU, Chung HC, Choi J, et al. Oral intake of low-molecular-weight collagen peptide improves hydration, elasticity, and wrinkling in human skin: a randomized, double-blind, placebo-controlled study. Nutrients. 2018;10(7):826.
- 4.Czajka A, Kania EM, Genovese L, et al. Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and has a beneficial effect on joint and general wellbeing. Nutr Res. 2018;57:97-108. PMID: 30122200.
- 5.Sood N, Baker WL, Coleman CI. Effect of glucomannan on plasma lipid and glucose concentrations, body weight, and blood pressure: systematic review and meta-analysis. Am J Clin Nutr. 2008;88(4):1167-1175. PMID: 18842808.
- 6.Zalewski BM, Chmielewska A, Szajewska H. The effect of glucomannan on body weight in overweight or obese children and adults: a systematic review of randomized controlled trials. Nutrition. 2015;31(3):437-442. PMID: 25701331.
- 7.Dolečková I, Kušnierik P, Berka V, et al. Oral sodium hyaluronate improves skin hydration, barrier function and signs of aging: a randomized, double-blind, placebo-controlled trial in 150 healthy adults. Sci Rep. 2025. PMID: 41422283.
- 8.Oral administration of hyaluronic acid to improve skin conditions via a randomized, double-blind clinical test. Skin Res Technol. 2023;29(11):e13531.
Pricing for IM8 and Tmrw reflects each brand’s own published subscription and one-time rates as listed on im8health.com and drinktmrw.com, verified on September 9, 2026.
Disclosures+
Advertising disclosure. This comparison is published by Healthful Seasons LLC, which manufactures and sells HS5. It is advertising. We have a direct financial interest in your purchase of HS5 and no financial relationship with, and no compensation from, IM8 or Tmrw.
Sources and accuracy. Information about IM8 and Tmrw, including serving weights, ingredient counts, dosages, pricing and quoted advertising language, reflects publicly available product data and marketing materials as of September 9, 2026. Formulations, doses, pricing and campaigns are subject to change. Where a value is listed as none or not included, this indicates the ingredient was not present or not disclosed at time of writing. Corrections may be sent to customerservice@healthfulseasons.com.
Reviews. HS5 star ratings and review counts reflect verified customer reviews collected through our independent review platform as of September 9, 2026. Reviews are unedited and include critical ratings.
Clinical disclosure. Natalie Bilinovich is a board-certified and practicing nurse practitioner specializing in dermatology. She is the clinical partner of Healthful Seasons. The content she authors for Healthful Seasons reflects her clinical perspective on ingredients and mechanisms relevant to dietary supplementation. It is not intended as personal medical advice and does not constitute a clinical recommendation for or against any prescription medication or treatment. Always consult your own healthcare provider before starting any supplement, especially if you are managing a health condition or taking prescription medications.
Not medical advice. Nothing on this page is medical advice. This article itself has not been reviewed by a clinician and nothing in it should be treated as a clinical recommendation. Always consult a qualified healthcare professional before starting any new supplement, particularly if you are pregnant, nursing, taking prescription medication or managing a health condition.
Trademarks. IM8 and Tmrw are trademarks of their respective owners. Healthful Seasons is not affiliated with, endorsed by, sponsored by or associated with either company.
Regulatory. These statements have not been evaluated by the Food and Drug Administration. HS5 is not intended to diagnose, treat, cure or prevent any disease, including menopause or any condition associated with it. Regular exercise and proper diet are needed to achieve and maintain weight loss. Individual results vary.